{"id":5580,"date":"2025-11-12T19:36:11","date_gmt":"2025-11-12T18:36:11","guid":{"rendered":"https:\/\/www.progettomitofusina2.com\/?p=5580"},"modified":"2025-11-15T10:39:29","modified_gmt":"2025-11-15T09:39:29","slug":"second-european-cmt-specialist-conference","status":"publish","type":"post","link":"https:\/\/www.progettomitofusina2.com\/en\/second-european-cmt-specialist-conference\/","title":{"rendered":"Second European CMT Specialist Conference"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mhwc96kj-c153025ccc643163317a0c0173f2c4f8\">\n.avia-image-container.av-mhwc96kj-c153025ccc643163317a0c0173f2c4f8 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-mhwc96kj-c153025ccc643163317a0c0173f2c4f8 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-mhwc96kj-c153025ccc643163317a0c0173f2c4f8 av-styling- avia-align-center  avia-builder-el-0  el_before_av_heading  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-5567 avia-img-lazy-loading-not-5567 avia_image ' src=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Untitled-design.png\" alt='' title='Untitled design'  height=\"650\" width=\"1200\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Untitled-design.png 1200w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Untitled-design-300x163.png 300w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Untitled-design-1030x558.png 1030w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Untitled-design-768x416.png 768w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Untitled-design-705x382.png 705w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mhwc77ze-9b7b505ff8efac948abde114f8fb8308\">\n#top .av-special-heading.av-mhwc77ze-9b7b505ff8efac948abde114f8fb8308{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-mhwc77ze-9b7b505ff8efac948abde114f8fb8308 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-mhwc77ze-9b7b505ff8efac948abde114f8fb8308 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-mhwc77ze-9b7b505ff8efac948abde114f8fb8308 av-special-heading-h2 blockquote modern-quote  avia-builder-el-1  el_after_av_image  el_before_av_textblock '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Second European CMT Specialist Conference<\/h2><div class='av-subheading av-subheading_below'><p>24-25 October 2025<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-mhwc4fq4-bafb134484abeea78cb3fb9e861d4312 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><section class=\"article\"><span style=\"font-size: 16px;\">From <\/span><strong style=\"font-size: 16px;\">24 to 25 October 2025<\/strong><span style=\"font-size: 16px;\">, the <\/span><strong style=\"font-size: 16px;\">University of Antwerp<\/strong><span style=\"font-size: 16px;\"> in Belgium hosted the <\/span><em style=\"font-size: 16px;\">Second European CMT Specialist Conference<\/em><span style=\"font-size: 16px;\">, organized by the <\/span><strong style=\"font-size: 16px;\">European CMT Federation<\/strong><span style=\"font-size: 16px;\">, of which we are founding members.<\/span><\/p>\n<p>The event was also the occasion to introduce the new consortium <strong>ECRA \u2013 European CMT Research Association<\/strong>, an exciting initiative promoted by the ECMTF to foster cooperation among CMT specialists across Europe, involving patient associations and pharmaceutical industries.<\/p>\n<p>\ud83d\udc49 <a href=\"https:\/\/ecmtf.org\/ecra_europeancmtresearchassociation\/\" target=\"_blank\" rel=\"noopener noreferrer\">Learn more about ECRA<\/a><\/p>\n<p>The conference brought together around <strong>150 clinicians, researchers, representatives of patient associations, pharmaceutical industry professionals,<\/strong> and <strong>policy makers<\/strong> from all over the world to discuss the latest scientific advances on <strong>Charcot-Marie-Tooth disease (CMT)<\/strong>.<\/p>\n<p>Throughout the conference, key topics were explored, ranging from <em>basic research<\/em> and <em>genetic diagnosis<\/em> to <em>clinical management<\/em> and the <em>development of new therapies<\/em>. Dedicated sessions also examined the growing role of <em>artificial intelligence<\/em> and <em>data sharing<\/em> in research on hereditary neuropathies.<\/p>\n<h3>OUR RESEARCH GROUP\u2019S PARTICIPATION<\/h3>\n<p>Thanks to the support and guidance of <strong>Prof. Stefania Corti<\/strong> and <strong>Dr. Federica Rizzo<\/strong>, two young researchers from the group we support at the <strong>Centro Dino Ferrari \u2013 Policlinico \u2013 University of Milan<\/strong>, <strong>Dr. Giulia Pagliari<\/strong> and <strong>Dr. Martina D\u2019Agostino<\/strong>, took part in the conference.<\/p>\n<p>They presented a <strong>poster<\/strong> highlighting the advances and experimental results of our research project on <strong>CMT2A \u2013 Mitofusin 2 (MFN2)<\/strong>.<\/p>\n<p>We are proud to see the growing international interest in <strong>CMT2A<\/strong>, with as many as <strong>four research projects on Mitofusin 2<\/strong> presented: our Italian study, one from France, one from the United States, and one from the United Kingdom.<br \/>\nThis international engagement gives hope for a faster path toward future therapeutic breakthroughs.<\/p>\n<h3>MAIN STUDIES ON MITOFUSIN 2 \u2013 CMT2A PRESENTED IN ANTWERP<\/h3>\n<p><strong>PL3-01 \u2013 Nathalie Bernard Marissal (Universit\u00e9 Aix-Marseille, France)<\/strong><br \/>\nPresented two therapeutic approaches for CMT2A: a <em>gene therapy<\/em> and a <em>pharmacological approach<\/em> using <strong>IFB-088<\/strong>. Both strategies showed promising results that deserve further exploration.<\/p>\n<p>\ud83d\udc49<em>\u00a0<a href=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Bernard-marissal-aix-marseille.pdf\">PL3-01 Bernard-Marissal \u2013 Aix Marseille\u00a0<\/a><\/em><\/p>\n<p><strong>P14 \u2013 Katherine Forsey (CMT Association, USA\/UK)<\/strong><br \/>\nDescribed the creation of an <em>in vitro motor neuron model<\/em> with the <strong>MFN2 R364W<\/strong> mutation, useful for studying the axonal and mitochondrial deficits typical of the disease.<br \/>\nThe study highlights the advantages of human cell models for faster and more efficient research.<\/p>\n<p>\ud83d\udc49 <em>\u00a0<a href=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/forsey-USA.pdf\">Poster P14 Forsey \u2013 USA USA<\/a><\/em><\/p>\n<p><strong>P26 \u2013 Our Research Project<\/strong><br \/>\nPresented by <strong>Dr. Martina D\u2019Agostino<\/strong>, within the group coordinated by <strong>Prof. Stefania Corti<\/strong> and <strong>Dr. Federica Rizzo<\/strong>.<br \/>\nThe study demonstrated that <strong>increasing MFN1 protein levels in a murine model of CMT2A<\/strong> has a highly protective effect, improving both axonal and mitochondrial function.<\/p>\n<p>\ud83d\udc49 <em>\u00a0<a href=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/dagostino-italia.pdf\">Poster P26 D\u2019Agostino \u2013 Italy<\/a><\/em><\/p>\n<p><strong>P32 \u2013 Lydia Jestice (University of Sheffield, UK)<\/strong><br \/>\nPresented an <em>in vitro model<\/em> based on <strong>induced pluripotent stem cells (iPSC)<\/strong> carrying the <strong>R94Q<\/strong> mutation, obtained through the <strong>CRISPR\/Cas9<\/strong> gene editing technique.<br \/>\nThis model allows detailed study of <em>axonal transport<\/em> mechanisms in CMT2A and the development of new hypotheses on disease pathogenesis.<\/p>\n<p>\ud83d\udc49 <em>\u00a0<a href=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Jestice-UK.pdf\">Poster P32 Jestice \u2013 UK<\/a><\/em><\/p>\n<p>\ud83d\udcc4 <a href=\"https:\/\/medialibrary.uantwerpen.be\/files\/2131715\/ade56002-bdbb-4287-affc-646472d6c05b.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Download the full Abstract Book (PDF)<\/a>, containing all the scientific abstracts presented at the conference, including ours.<\/p>\n<h3>AN EXPERIENCE OF GROWTH AND COLLABORATION<\/h3>\n<p>The participation of our young researchers in the Antwerp conference represented an important moment of <strong>scientific exchange<\/strong> and <strong>international collaboration<\/strong>, as well as recognition of the work carried out within our <strong>CMT2A research project<\/strong>.<\/p>\n<p>We would like to warmly thank <strong>Prof. Stefania Corti<\/strong> and <strong>Dr. Federica Rizzo<\/strong> for making this participation possible, and <strong>Dr. Giulia Pagliari<\/strong> and <strong>Dr. Martina D\u2019Agostino<\/strong> for representing our research group with professionalism and passion at such a high-level scientific event.<\/p>\n<\/section>\n<\/div><\/section>\n<div  class='flex_column av-av_one_full-a93934ecd89fbb8a9566d39e89cd3725 av_one_full  avia-builder-el-3  el_after_av_textblock  avia-builder-el-last  first flex_column_div  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mi03hscz-83177b8d89924d1bebc3c1b5d5e44789\">\n.av-horizontal-gallery.av-mi03hscz-83177b8d89924d1bebc3c1b5d5e44789{\npadding:3.75% 0px;;\n}\n.av-horizontal-gallery.av-mi03hscz-83177b8d89924d1bebc3c1b5d5e44789 .av-horizontal-gallery-inner{\npadding-bottom:25%;\n}\n<\/style>\n<div  class='av-horizontal-gallery av-mi03hscz-83177b8d89924d1bebc3c1b5d5e44789 av-horizontal-gallery-large-gap av-horizontal-gallery-enlarge-effect  avia-builder-el-4  avia-builder-el-no-sibling  av-slideshow-ui av-control-default av-slideshow-manual 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https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-768x1365.jpeg 768w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-864x1536.jpeg 864w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-844x1500.jpeg 844w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-397x705.jpeg 397w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1.jpeg 1134w\" sizes=\"(max-width: 579px) 100vw, 579px\" \/><a href=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-579x1030.jpeg\" data-srcset=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-579x1030.jpeg 579w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-169x300.jpeg 169w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-768x1365.jpeg 768w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-864x1536.jpeg 864w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-844x1500.jpeg 844w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1-397x705.jpeg 397w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2025\/11\/Unknown-4-1.jpeg 1134w\" data-sizes=\"(max-width: 579px) 100vw, 579px\" class='av-horizontal-gallery-link' aria-hidden='true' data-av_icon='\ue869' data-av_iconfont='entypo-fontello' title='Unknown-4' alt=''><\/a><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>24-25 October 2025<br \/>\nFrom 24 to 25 October 2025, the University of Antwerp in Belgium hosted the Second European CMT Specialist Conference, organized by the European CMT Federation, of which we are founding members.<\/p>\n","protected":false},"author":2,"featured_media":5569,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[118,63],"tags":[],"class_list":["post-5580","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2024-news-and-events","category-news-and-events"],"_links":{"self":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/5580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/comments?post=5580"}],"version-history":[{"count":13,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/5580\/revisions"}],"predecessor-version":[{"id":5629,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/5580\/revisions\/5629"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media\/5569"}],"wp:attachment":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media?parent=5580"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/categories?post=5580"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/tags?post=5580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}