{"id":4597,"date":"2024-03-26T16:21:37","date_gmt":"2024-03-26T15:21:37","guid":{"rendered":"https:\/\/www.progettomitofusina2.com\/?p=4597"},"modified":"2024-03-26T18:22:29","modified_gmt":"2024-03-26T17:22:29","slug":"biomarkers-in-cmt2a-patients","status":"publish","type":"post","link":"https:\/\/www.progettomitofusina2.com\/en\/biomarkers-in-cmt2a-patients\/","title":{"rendered":"Biomarkers in CMT2A patients"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lu8n6d7j-bf30bb7803252e1b99cff4b6f6c2890a\">\n.avia-image-container.av-lu8n6d7j-bf30bb7803252e1b99cff4b6f6c2890a img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lu8n6d7j-bf30bb7803252e1b99cff4b6f6c2890a .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lu8n6d7j-bf30bb7803252e1b99cff4b6f6c2890a av-styling- avia-align-center  avia-builder-el-0  el_before_av_heading  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-4591 avia-img-lazy-loading-not-4591 avia_image ' src=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2024\/03\/biomarcatoriCMT2A.jpg\" alt='' title='biomarcatoriCMT2A'  height=\"650\" width=\"1200\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2024\/03\/biomarcatoriCMT2A.jpg 1200w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2024\/03\/biomarcatoriCMT2A-300x163.jpg 300w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2024\/03\/biomarcatoriCMT2A-1030x558.jpg 1030w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2024\/03\/biomarcatoriCMT2A-768x416.jpg 768w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2024\/03\/biomarcatoriCMT2A-705x382.jpg 705w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lu8n5z08-4b8b8c7b574e1be9672f11ee9941d8a7\">\n#top .av-special-heading.av-lu8n5z08-4b8b8c7b574e1be9672f11ee9941d8a7{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-lu8n5z08-4b8b8c7b574e1be9672f11ee9941d8a7 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-lu8n5z08-4b8b8c7b574e1be9672f11ee9941d8a7 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-lu8n5z08-4b8b8c7b574e1be9672f11ee9941d8a7 av-special-heading-h2 blockquote modern-quote  avia-builder-el-1  el_after_av_image  el_before_av_textblock '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >A new research project to identify biomarkers for the CMT2A<\/h2><div class='av-subheading av-subheading_below'><p>26 marzo 2024<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-lu8n3nej-206cae2e45e329e80fd10700d73e9075 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span class=\"\" data-index=\"0\">A new research project is underway, supported by our association and carried out by the team of Professor Stefania Corti of the Dino Ferrari Centre\/University of Milan (Doctors Rizzo, Abati and Anastasia).<\/span><\/p>\n<p><span class=\"\" data-index=\"1\">The project aims to identify (or with other pathologies due to mutation of Mitofusin 2), the presence, in the blood of patients with CMT2A, of possible biomarkers of disease that may be useful to diagnose and\/or control the development of pathology.<\/span><\/p>\n<p><span data-index=\"2\"><strong>What are biomarkers?<\/strong><br \/>\n<\/span><span class=\"\" data-index=\"3\">A biomarker is a biological signal (such as a DNA sequence or a protein) whose presence in the body is linked to a certain disease. <\/span><span class=\"\" data-index=\"4\">To be valid, however, it must be possible to measure it accurately, reliably and quickly.<\/span><\/p>\n<p><span data-index=\"5\"><strong>Why are they important for the CMT2A?<\/strong><br \/>\n<\/span><span class=\"\" data-index=\"6\">Recent research has shown that patients with Charcot-Marie-Tooth disease have higher levels of certain proteins in their blood serum (however, these findings need further confirmation, and so far no specific study has investigated the serum of patients with CMT2A).<\/span><\/p>\n<p><span data-index=\"7\"><strong>THE SCIENTIFIC STUDY<\/strong><br \/>\n<\/span><span class=\"\" data-index=\"8\">Biomarkers in the blood are gaining more and more popularity as affordable and low-cost tools to guide diagnosis and control the development of a disease.<\/span><\/p>\n<p><span class=\"\" data-index=\"9\">In the case of CMT, they can play an important role because these diseases have a slow clinical progression that can make it difficult to observe changes in the short term. <\/span><span data-index=\"10\">In addition, they could help to better clarify the mechanisms responsible for the disease.<\/span><\/p>\n<p><span class=\"\" data-index=\"11\">No study has already evaluated blood biomarkers in CMT2A because research on blood has so far concentrated on the most common subtype (CMT1A). <\/span><span class=\"\" data-index=\"12\">This is the first one.<\/span><\/p>\n<p>Overall, with many new therapies close to testing, it is crucial to find molecular biomarkers through which you can evaluate the effectiveness of treatments on this slowly progressing disease.<\/p>\n<p><strong>Research purpose<\/strong><br \/>\nThe aim of this project, therefore, is to investigate potential serous biomarkers of CMT2A in order to find a method (low cost and easily accessible) to make diagnoses and to evaluate therapeutic efficacy in studies.<\/p>\n<p><strong>Experimental plan<\/strong><br \/>\nExperimental research consists of 3 steps:<\/p>\n<ol>\n<li>Collection of serum from patients with CMT2A and mouse models<\/li>\n<li>Evaluation of serum proteins selected by enzymatic immunosorbent test (ELISA)<\/li>\n<li>Evaluation of microRNAs selected by real-time PCR. Circulating myrrh will be isolated from the same serum using a special kit.<\/li>\n<\/ol>\n<p><strong>Who can participate in the study?\u00a0<\/strong><br \/>\nCurrently limited only to Italy.<\/p>\n<p>For more info, you should contact Doctor Claudia Alberti at<a href=\"mailto:claudia.alberti@unimi.it\"> claudia.alberti@unimi.it<\/a><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>26 marzo 2024<br \/>\nA new research project is underway, supported by our association and carried out by the team of Professor Stefania Corti of the Dino Ferrari Centre\/University of Milan<\/p>\n","protected":false},"author":2,"featured_media":4588,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75,98,63],"tags":[101,103,102],"class_list":["post-4597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2022-en","category-2023-news-and-events","category-news-and-events","tag-charcotmarietooth","tag-cmt2a-2","tag-mitofusin2"],"_links":{"self":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/4597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/comments?post=4597"}],"version-history":[{"count":3,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/4597\/revisions"}],"predecessor-version":[{"id":4601,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/4597\/revisions\/4601"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media\/4588"}],"wp:attachment":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media?parent=4597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/categories?post=4597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/tags?post=4597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}