{"id":2369,"date":"2015-06-17T15:08:00","date_gmt":"2015-06-17T13:08:00","guid":{"rendered":"https:\/\/www.progettomitofusina2.com\/la-riparazione-dei-geni-difettosi-con-la-tecnica-del-silenziamento-genico\/"},"modified":"2022-06-13T09:01:52","modified_gmt":"2022-06-13T07:01:52","slug":"repairing-screwed-up-genes-by-silencing-them","status":"publish","type":"post","link":"https:\/\/www.progettomitofusina2.com\/en\/repairing-screwed-up-genes-by-silencing-them\/","title":{"rendered":"Repairing screwed-up genes by silencing them"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l2kg9m0w-048aaf1204e156bd9630fba127b5df2b\">\n.avia-image-container.av-l2kg9m0w-048aaf1204e156bd9630fba127b5df2b img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-l2kg9m0w-048aaf1204e156bd9630fba127b5df2b .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-l2kg9m0w-048aaf1204e156bd9630fba127b5df2b av-styling- avia-align-center  avia-builder-el-0  el_before_av_heading  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-1631 avia-img-lazy-loading-not-1631 avia_image ' src=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2022\/04\/1500x630-News_36.jpg\" alt='' title='1500x630-News_36'  height=\"630\" width=\"1500\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2022\/04\/1500x630-News_36.jpg 1500w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2022\/04\/1500x630-News_36-300x126.jpg 300w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2022\/04\/1500x630-News_36-1030x433.jpg 1030w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2022\/04\/1500x630-News_36-768x323.jpg 768w, https:\/\/www.progettomitofusina2.com\/wp-content\/uploads\/2022\/04\/1500x630-News_36-705x296.jpg 705w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l2kg5x73-3e903e93b2e3de7cdb75750fc6493f41\">\n#top .av-special-heading.av-l2kg5x73-3e903e93b2e3de7cdb75750fc6493f41{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l2kg5x73-3e903e93b2e3de7cdb75750fc6493f41 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l2kg5x73-3e903e93b2e3de7cdb75750fc6493f41 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l2kg5x73-3e903e93b2e3de7cdb75750fc6493f41 av-special-heading-h2 blockquote modern-quote  avia-builder-el-1  el_after_av_image  el_before_av_textblock '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >Repairing screwed-up genes by silencing them<\/h2><div class='av-subheading av-subheading_below'><p>19 June 2015<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-l2kg939m-7a2c3184e1413d1bb90befa298813f22 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Research for the treatment of rare diseases marked a decisive step forward.<\/p>\n<p>The first\u00a0<strong>human clinical trial<\/strong>\u00a0for the cure of Huntington disease, a disorder originated from DNA-altering, will soon take place in London. The interesting thing about it, as reported in the\u00a0<a href=\"http:\/\/www.lastampa.it\/2015\/06\/18\/scienza\/tuttoscienze\/il-futuro-delle-cure-dellhuntington-nella-riparazione-dei-geni-difettosi-qtsKyniaFthMThzRmo4C4L\/pagina.html\">article<\/a>\u00a0written by Laura Zuccato (Professor of Pharmacology at Milan University) for an important Italian newspaper, is the technique they are going to use, the\u00a0<strong>Gene Silencing<\/strong>, which is the same employed by our researchers in the laboratory of the Dino Ferrari Centre for the treatment of CMT2A, in particular in the Scientific Project we have been funding for the last three years.<br \/>\nIn our case, we are dealing with the silencing of Mitofusin 2 screwed-up gene and this stage of the trial made in laboratory with mouse model has paid off.<br \/>\nWe are looking forward to have the test results of the London study, hoping that this clinical trial is going to open up new avenues for trials in the field of genic neuropathies due to Mitofusine 2.<\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>19 June 2015<br \/>\nResearch for the treatment of rare diseases marked a decisive step forward&#8230;<\/p>\n","protected":false},"author":1,"featured_media":1631,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68,63],"tags":[],"class_list":["post-2369","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2015-en","category-news-and-events"],"_links":{"self":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/2369","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/comments?post=2369"}],"version-history":[{"count":5,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/2369\/revisions"}],"predecessor-version":[{"id":2375,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/posts\/2369\/revisions\/2375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media\/1631"}],"wp:attachment":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media?parent=2369"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/categories?post=2369"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/tags?post=2369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}