{"id":4502,"date":"2024-01-10T16:06:31","date_gmt":"2024-01-10T15:06:31","guid":{"rendered":"https:\/\/www.progettomitofusina2.com\/?post_type=portfolio&#038;p=4502"},"modified":"2024-01-11T15:28:34","modified_gmt":"2024-01-11T14:28:34","slug":"cmt2a-identification-of-a-potential-therapeutic-approach","status":"publish","type":"portfolio","link":"https:\/\/www.progettomitofusina2.com\/en\/portfolio-articoli\/cmt2a-identification-of-a-potential-therapeutic-approach\/","title":{"rendered":"CMT2A: identification of a potential therapeutic approach"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lr9awsst-9f2dbed4979f1be5527bfbf30d27c536\">\n#top .av-special-heading.av-lr9awsst-9f2dbed4979f1be5527bfbf30d27c536{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-lr9awsst-9f2dbed4979f1be5527bfbf30d27c536 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-lr9awsst-9f2dbed4979f1be5527bfbf30d27c536 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-lr9awsst-9f2dbed4979f1be5527bfbf30d27c536 av-special-heading-h2 blockquote modern-quote  avia-builder-el-0  el_before_av_textblock  avia-builder-el-first '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >CM2A: identification of a potential therapeutic approach<\/h2><div class='av-subheading av-subheading_below'><p>Milan, November 27th, 2023<\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-lr9ayaur-4886b4d85d2383d979e2540078e0d85f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>A recent study conducted by researchers from the \u201c<strong>Dino Ferrari Center<\/strong>\u201d, <strong>University of Milan, IRCCS Fondazione Ca&#8217; Granda Ospedale Maggiore Policlinico<\/strong>, and accepted for online publication in the rivista <strong><em><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-023-05018-w\">Cellular Molecular Life Science<\/a><\/em><\/strong>, has demonstrated the effectiveness of a gene therapy approach in an experimental model of <strong>Charcot-Marie-Tooth disease type 2A (CMT2A)<\/strong>.<\/p>\n<p>CMT2A is a sensorimotor polyneuropathy associated with mutations in the <em>Mitofusin 2<\/em> <em>(MFN2<\/em>) gene and characterized by the degeneration of motor and sensory axons in the peripheral nerves. Currently, the treatment is supportive and there is no effective therapy in preventing the disease-related neurodegeneration. One of the main challenges in the treatment of this pathology lies not only in the absence of the functional MFN2 protein, but also in the presence of a toxic variant of this protein. A combined approach of gene replacement and silencing, respectively capable of expressing the &#8220;healthy&#8221; gene and switching off the &#8220;sick&#8221; one, may constitute an ideal therapeutic approach for this disease.<\/p>\n<p>The principal investigator of this research is Prof. <strong>Stefania Corti<\/strong>, currently head of the Neural Stem Cell Laboratory in the Department of Pathophysiology and Transplantation of the University of Milan. The research group included other members of the laboratory and researchers from the \u201c<strong>Dino Ferrari Center<\/strong>\u201d of the <strong>University of Milan and from the IRCCS Fondazione Ca&#8217; Granda Ospedale Maggiore Policlinico<\/strong>. In addition, the group collaborated with King&#8217;s College, the &#8220;Romeo ed Enrica Invernizzi&#8221; Institute of Molecular Genetics, the Department of Biomedical Sciences of the Humanitas University, the Carlo Besta Neurological Institute and the Preclinical research center of the IRCCS Ca&#8217; Granda Ospedale Maggiore Policlinico Foundation.<\/p>\n<p>Dr. <strong>Federica Rizzo<\/strong>, first author of this research work, and her colleagues demonstrated how this combined approach of silencing the defective MFN2 gene and restoring the healthy gene led to an improvement in the characteristics of the disease in an <em>in vitro<\/em> model consisting of motor neurons derived from induced pluripotent stem cells of patients affected by CMT2A.<\/p>\n<p>The molecular correction was also confirmed in a mouse model of CMT2A by local injection into the Central Nervous System of an Adeno-Associated AAV9 vector carrying the healthy <em>MFN2<\/em> gene and the silencing construct.<\/p>\n<p>This study provides the first &#8220;proof of principle&#8221; of the effectiveness of this treatment for CMT2A and testifies the perseverance of Prof Corti&#8217;s research group in studying this pathology and identifying possible therapeutic strategies.<\/p>\n<p>The research was conducted with the support of the <strong>Associazione<\/strong> <strong>Dino Ferrari Center<\/strong>, dell\u2019<strong>Associazione Progetto Mitofusina2 onlus<\/strong>, of the <strong>Ministry of Health<\/strong>, as part of the Young Researchers Research Project &#8211; GR- 2018-12365358 funded 2018\u20132021, and of the <strong>Telethon Foundation<\/strong> as part of the GGP19002 project.<\/p>\n<p class=\"heading-title\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/\"><strong>Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot-Marie-Tooth type 2A<\/strong><\/a><\/p>\n<p><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rizzo+F&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Federica Rizzo\">Federica Rizzo<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bono+S&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Silvia Bono\">Silvia Bono<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ruepp+MD&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Marc David Ruepp\">Marc David Ruepp<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-2\">2<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Salani+S&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Sabrina Salani\">Sabrina Salani<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ottoboni+L&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Linda Ottoboni\">Linda Ottoboni<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Abati+E&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Elena Abati\">Elena Abati<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Melzi+V&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Valentina Melzi\">Valentina Melzi<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cordiglieri+C&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Chiara Cordiglieri\">Chiara Cordiglieri<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Istituto Di Genetica Molecolare \" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-3\">3<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pagliarani+S&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Serena Pagliarani\">Serena Pagliarani<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=De+Gioia+R&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Roberta De Gioia\">Roberta De Gioia<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Anastasia+A&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Alessia Anastasia\">Alessia Anastasia<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Taiana+M&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Michela Taiana\">Michela Taiana<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Garbellini+M&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Manuela Garbellini\">Manuela Garbellini<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lodato+S&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Simona Lodato\">Simona Lodato<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-4\">4<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"IRCCS Humanitas Research Hospital, Rozzano, 20089, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-5\">5<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Kunderfranco+P&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Paolo Kunderfranco\">Paolo Kunderfranco<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-4\">4<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"IRCCS Humanitas Research Hospital, Rozzano, 20089, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-5\">5<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cazzato+D&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Daniele Cazzato\">Daniele Cazzato<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-6\">6<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cartelli+D&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Daniele Cartelli\">Daniele Cartelli<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-6\">6<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lonati+C&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Caterina Lonati\">Caterina Lonati<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Center for Preclinical Research, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20100, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-7\">7<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bresolin+N&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Nereo Bresolin\">Nereo Bresolin<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-8\">8<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Comi+G&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Giacomo Comi\">Giacomo Comi<\/a><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-8\">8<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Nizzardo+M&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Monica Nizzardo\">Monica Nizzardo<\/a><sup class=\"equal-contrib-container\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"equal-contrib\" title=\"Contributed equally\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-equal-contrib-explanation\">#<\/a><\/sup><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-1\">1<\/a><\/sup><span class=\"comma\">,\u00a0<\/span><\/span><span class=\"authors-list-item \"><a class=\"full-name\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Corti+S&amp;cauthor_id=38007410\" data-ga-category=\"search\" data-ga-action=\"author_link\" data-ga-label=\"Stefania Corti\">Stefania Corti<\/a><sup class=\"equal-contrib-container\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"equal-contrib\" title=\"Contributed equally\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-equal-contrib-explanation\">#<\/a><\/sup><sup class=\"affiliation-links\"><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Milan, Italy. stefania.corti@unimi.it.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-9\">9<\/a><span class=\"author-sup-separator\">\u00a0<\/span><a class=\"affiliation-link\" title=\"Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Neuromuscular and Rare Diseases Unit, Milan, Italy. stefania.corti@unimi.it.\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/#full-view-affiliation-10\">10<\/a><\/sup><\/span><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"<p>Milan, November 27th, 2023<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"portfolio_entries":[80,8],"class_list":["post-4502","portfolio","type-portfolio","status-publish","hentry","portfolio_entries-latest-news-on-scientific-research","portfolio_entries-news-sulla-ricerca"],"_links":{"self":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/portfolio\/4502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/portfolio"}],"about":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/types\/portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/comments?post=4502"}],"version-history":[{"count":1,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/portfolio\/4502\/revisions"}],"predecessor-version":[{"id":4503,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/portfolio\/4502\/revisions\/4503"}],"wp:attachment":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media?parent=4502"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/tags?post=4502"},{"taxonomy":"portfolio_entries","embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/portfolio_entries?post=4502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}