{"id":2226,"date":"2022-04-28T14:49:14","date_gmt":"2022-04-28T12:49:14","guid":{"rendered":"https:\/\/www.progettomitofusina2.com\/?page_id=2226"},"modified":"2024-01-11T15:33:37","modified_gmt":"2024-01-11T14:33:37","slug":"scientific-publications","status":"publish","type":"page","link":"https:\/\/www.progettomitofusina2.com\/en\/resources\/scientific-publications\/","title":{"rendered":"SCIENTIFIC PUBLICATIONS"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l2izks4u-95c183938823c251481fd6d8f3d8e3e9\">\n#top .av-special-heading.av-l2izks4u-95c183938823c251481fd6d8f3d8e3e9{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-l2izks4u-95c183938823c251481fd6d8f3d8e3e9 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-l2izks4u-95c183938823c251481fd6d8f3d8e3e9 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l2izks4u-95c183938823c251481fd6d8f3d8e3e9 av-special-heading-h2  avia-builder-el-0  el_before_av_textblock  avia-builder-el-first '><h2 class='av-special-heading-tag '  itemprop=\"headline\"  >SCIENTIFIC PUBLICATIONS<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-l2izl6rf-7276d124cb8a3890335b60fff6beb094 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><strong>ITALY<\/strong><\/h3>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38007410\/\">Combined RNA interference and gene replacement therapy targeting MFN2 as proof of principle for the treatment of Charcot-Marie-Tooth type 2A<\/a><\/li>\n<li><a href=\"https:\/\/www.jci.org\/articles\/view\/161566\">A SARM1\/mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model<\/a><\/li>\n<li><a href=\"https:\/\/jnnp.bmj.com\/content\/90\/10\/1171\" target=\"_blank\" rel=\"noopener\">Expanding the Spectrum of Genes Responsible for Hereditary Motor Neuropathies<\/a><\/li>\n<\/ul>\n<div>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26306937\">Mutational mechanisms in MFN2-related neuropathy: compound heterozygosity for recessive and semidominant mutations.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26306937\">A mutation in the heptad repeat 2 domain of MFN2 in a large CMT2A family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29361379\" target=\"_blank\" rel=\"noopener\">A novel homozygous MFN2 mutation associated with severe and atypical CMT2 phenotype.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29309902\">Highlighting the endoplasmic reticulum-mitochondria connection: Focus on Mitofusin 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29309902\">Mitofusin 2: from functions to disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29721168\" target=\"_blank\" rel=\"noopener\">Recruitment of mitofusin 2 into &#8220;lipid rafts&#8221; drives mitochondria fusion induced by Mdivi-1.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29721168\" target=\"_blank\" rel=\"noopener\">Newly Discovered MFN2 Gene Mutation Linked to Severe Form of CMT Type 2A, Study Reports<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28215760\" target=\"_blank\" rel=\"noopener\">Two novel cases of compound heterozygous mutations in mitofusin2: Finding out the inheritance.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/congress.wooky.it\/web\/eventi\/NEURO2016\/poster\/pdf\/pst388.pdf\" target=\"_blank\" rel=\"noopener\">Superimposed inflammatory neuropathy in pa2ents affected by Charcot-Marie-Tooth neuropathy<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/congress.wooky.it\/web\/eventi\/NEURO2016\/poster\/pdf\/pst388.pdf\" target=\"_blank\" rel=\"noopener\">Testing overwork weakness in Charcot-Marie-Tooth (CMT) disease: is it true or false?<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28286897\" target=\"_blank\" rel=\"noopener\">Charcot-Marie-Tooth disease: genetic subtypes in the Sardinian population.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28286897\" target=\"_blank\" rel=\"noopener\">Charcot-Marie-Tooth neuropathy misdiagnosed as chronic inflammatory demyelinating polyradiculoneuropathy<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/congress.wooky.it\/web\/eventi\/NEURO2016\/poster\/pdf\/pst119.pdf\" target=\"_blank\" rel=\"noopener\">Quantifying gait impairment in individuals affected by Charcot-Marie-Tooth disease: the usefulness of gait profile score and gait variable score.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/congress.wooky.it\/web\/procedure\/protocollo.cfm?List=AmbienteIdEvento,WsIdSessione,WsIdEvento,WsIdDomanda,WsPageNameCaller,contenuti&amp;c1=NEURO2016&amp;c2=L2&amp;c3=NEURO2016&amp;c4=186&amp;c5=%2Fweb%2Fprocedure%2Fprotocollo.cfm%3FList%3DAmbienteIdEvento%26c1%3DNEURO2016&amp;c6=poster\" target=\"_blank\" rel=\"noopener\">Sport activity in Charcot\u2013Marie\u2013Tooth disease: A case study of a Paralympic swimmer<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5026044\/\" target=\"_blank\" rel=\"noopener\">Pseudomyopathic course in a patient with charcot-marie-tooth disease: report of a novel MFN2 mutation<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26989944\" target=\"_blank\" rel=\"noopener\">Charcot-Marie-Tooth type 2 and distal hereditary motor neuropathy: clinical, neurophysiological and genetic finding from a single centre experience<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27506976\" target=\"_blank\" rel=\"noopener\">Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons.<\/a><\/li>\n<\/ul>\n<\/div>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27043305\" target=\"_blank\" rel=\"noopener\">Phenotypic Variability of Childhood Charcot-Marie-Tooth Disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4581235\/\" target=\"_blank\" rel=\"noopener\">Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.telethon.it\/ricerca-progetti\/progetti-finanziati\/dettagli\/genetic-diseases-of-mitochondrial-shape-integrated-approaches-to-understand-pathogenesis\" target=\"_blank\" rel=\"noopener\">Malattie genetiche della forma dei mitocondri: approcci integrati per comprenderne la patogenesi e definirne strategie terapeutiche. Studio in corso.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25847151\">Mitochondrial dynamics and inherited peripheral nerve diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25957633\">Acute optic neuropathy associated with a novel MFN2 mutation.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26143526\">MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26306937\">Mutational mechanisms in MFN2-related neuropathy: compound heterozygosity for recessive and semidominant mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26307494\">Early onset Charcot-Marie-Tooth neuropathy type 2A and severe developmental delay: expanding the clinical phenotype of MFN2-related neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26028275\">The influence of somatosensory and muscular deficits on postural stabilization: Insights from an instrumented analysis of subjects affected by different types of Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25847151\">Mitochondrial dynamics and inherited peripheral nerve diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23929728\">Novel mutation of the mitofusin 2 gene in a family with Charcot-Marie-Tooth disease type 2 (CMT2A<\/a>)<\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24006477\">Mitochondrial fusion proteins and human diseases<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24485836\">Mitochondria and melanosomes establish physical contacts modulated by Mfn2 and involved in organelle biogenesis.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25295627\">The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25439726\">Truncating and missense mutations in IGHMBP2 cause Charcot-Marie Tooth disease type 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25429913\">Charcot-Marie-Tooth disease: frequency of genetic subtypes in a Southern Italy population.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23931817\">Dominant Charcot-Marie-Tooth syndrome and cognate disorders<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21623771\">Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20951042\">Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: a new model for Charcot-Marie-Tooth type 2A neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20951041\">Co-occurrence of amyotrophic lateral sclerosis and Charcot-Marie-Tooth disease type 2A in a patient with a novel mutation in the mitofusin-2 gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21601224\">Clinical, electrophysiological and pathological findings of a patient with CMT2 due to the p.Ala738Val mitofusin 2 mutation.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20660910\">Heat shock protein 27 R127W mutation: evidence of a continuum between axonal Charcot-Marie-Tooth and distal hereditary motor neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21623771\">The GST domain of GDAP1 is a frequent target of mutations in the dominant form of axonal Charcot Marie Tooth type 2K.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20537790\">A case of CMT 1B due to Val 102\/fs null mutation of the MPZ gene presenting as hyperCKemia.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19657941\">An axon regeneration signature in a Charcot-Marie-Tooth disease type 2 patient.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19293842\">Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/jnnp.bmj.com\/content\/78\/11\/1286.extract?sid=65ddb37e-11d7-4b5b-b223-352713a58480\">A novel founder mutation in the MFN2 gene associated with variable Charcot\u2013Marie\u2013Tooth type 2 phenotype in two families from Southern Italy<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>FRANCE<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26686600\">Clinical and allelic heterogeneity in a pediatric cohort of 11 patients carrying MFN2 mutation.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26686600\">Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26246519\">Charcot-Marie-Tooth diseases: an update and some new proposals for the classification.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24957169\">Charcot-Marie-Tooth disease type 2A: from typical to rare phenotypic and genotypic features<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22189565\">The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy &#8216;plus&#8217; phenotype.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22433900\">Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22546700\">A French family with Charcot-Marie-Tooth disease related to simultaneous heterozygous MFN2 and GDAP1 mutations<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23147504\">Mitochondria and peripheral neuropathies<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20849849\">Mitochondrial dysfunction and pathophysiology of Charcot-Marie-Tooth disease involving GDAP1 mutations<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21285398\">Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19718987\">[Ultrastructural lesions of axonal mitochondria in patients with childhood-onset Charcot-Marie-Tooth disease due to MFN2 mutations].<br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18957892\">Genotype-phenotype correlations in Charcot-Marie-Tooth disease type 2 caused by mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18957892\">Histopathological findings in hereditary motor and sensory neuropathy of axonal type with onset in early childhood associated with mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17444508\">Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease.<\/a><\/li>\n<\/ul>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311851\">\u00a0<\/a><\/p>\n<hr \/>\n<h3>GREAT BRITAIN<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29520876\" target=\"_blank\" rel=\"noopener\">Severe cognitive impairment in a patient with CMT2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28063088\" target=\"_blank\" rel=\"noopener\">Mosaicism for a pathogenic MFN2 mutation causes minimal clinical features of CMT2A in the parent of a severely affected child.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26114802\">MFN2 deletion of exons 7 and 8: founder mutation in the UK population.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24198383\">Recessive axonal Charcot-Marie-Tooth disease due to compound heterozygous mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25582960\">A pilot study of proximal strength training in Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25519471\">Interventions for fatigue in peripheral neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23840650\">Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23840650\">Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>SPAIN<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30569560\">Genetic epidemiology, demographic and clinical characteristics of Charcot-Marie-Tooth disease in the island of Gran Canaria (Spain).<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30569560\">Mitofusin 2 as a driver that controls energy metabolism and insulin signaling.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26113818\">Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25567790\">Mitofusin 2 as a driver that controls energy metabolism and insulin signaling.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21703725\">[Guidelines for molecular diagnosis of Charcot-Marie-Tooth disease].<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20544920\">Charcot-Marie-Tooth disease with intermediate conduction velocities caused by a novel mutation in the MPZ gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19889647\">Phenotypic spectrum of MFN2 mutations in the Spanish population<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19448711\">Regulation of mitofusin-2 expression in skeletal muscle<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21703725\">Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>ICELAND<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19893324\">Prevalence of symptomatic Charcot-Marie-Tooth disease in Iceland: a study of a well-defined population.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>SWITZERLAND<\/h3>\n<ul>\n<li><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22179580\">Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21526202\">An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/brain.oxfordjournals.org\/content\/133\/5\/1460\">Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot\u2013Marie\u2013Tooth neuropathy type 2A<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19427854\">Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>SERBIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21546779\">Epidemiology of Charcot-Marie-Tooth disease in the population of Belgrade, Serbia.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>SWEDEN<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28348166\">Mfn2 is critical for brown adipose tissue thermogenic function.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28348166\">Exploratory study of physical activity in persons with Charcot-Marie-Tooth disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18579801\">Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1049919\/\">Charcot-Marie-Tooth disease in northern Sweden: pedigree analysis and the presence of the duplication in chromosome 17p11.2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8333247\">Charcot-Marie-Tooth disease in northern Sweden: an epidemiological and clinical study<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>BELGIUM<\/h3>\n<ul>\n<li><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs13311-016-0501-z\" target=\"_blank\" rel=\"noopener\">Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006899320300482?via%3Dihub\" target=\"_blank\" rel=\"noopener\">HDAC6 Inhibitors: Translating Genetic and Molecular Insights Into a Therapy for Axonal CMT<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21840889\">Genetic spectrum of hereditary neuropathies with onset in the first year of life.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16714318\">MFN2 mutation distribution and genotype\/phenotype correlation in Charcot-Marie-Tooth type 2.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>GERMANY<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25850958\">Diagnostic algorithms in Charcot-Marie-Tooth neuropathies: experiences from a German genetic laboratory on the basis of 1206 index patients<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25688136\">Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22926664\">Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23711354\">Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23743332\">Charcot-Marie-Tooth disease: frequency of genetic subtypes in a German neuromuscular center population<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18826755\">Late onset autosomal dominant Charcot-Marie-Tooth 2 neuropathy in a Costa Rican family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18425620\">Cerebral involvement in axonal Charcot-Marie-Tooth neuropathy caused by mitofusin2 mutations.<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18826755\"><br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16762064\">Charcot-Marie-Tooth neuropathy type 2A: novel mutations in the mitofusin 2 gene (MFN2).<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19109886\">Mitofusin 2 builds a bridge between ER and mitochondria<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18425620\">Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A).<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>NORWAY<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23106488\">Genetic epidemiology of Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.biomedcentral.com\/1471-2350\/11\/48\"><em>MFN2<\/em>\u00a0point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20482598\">Genetic epidemiology of Charcot-Marie-Tooth in the general population.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.biomedcentral.com\/1471-2350\/14\/94\">Diagnostic laboratory testing for Charcot Marie Tooth disease (CMT): the spectrum of gene defects in Norwegian patients with CMT and its implications for future genetic test strategies<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>AUSTRIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21892769\">SNP array-based whole genome homozygosity mapping as the first step to a molecular diagnosis in patients with Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>CYPRUS<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20571287\">Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic characteristics.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>POLAND<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28076385\" target=\"_blank\" rel=\"noopener\">The Effect of a Novel c.820C&gt;T (Arg274Trp) Mutation in the Mitofusin 2 Gene on Fibroblast Metabolism and Clinical Manifestation in a Patient.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25574749\">Mitofusin 2 expression dominates over mitofusin 1 exclusively in mouse dorsal root ganglia &#8211; a possible explanation for peripheral nervous system involvement in Charcot-Marie-Tooth 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24803844\">A late-onset and mild form of Charcot-Marie-Tooth disease type 2 caused by a novel splice-site mutation within the Mitofusin-2 gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17874344\">[Mutations in the mitofusin 2 gene are the most common cause of Charcot-Marie-Tooth type 2 disease].<\/a><\/li>\n<\/ul>\n<h3><\/h3>\n<hr \/>\n<h3>TURKEY<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19381883\">Novel GDAP1 mutation in a Turkish family with CMT2K (CMT2K with novel GDAP1 mutation). <\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>USA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14992027.2019.1633022\" target=\"_blank\" rel=\"noopener\">The Audiologic Profile of Patients With Charcot-Marie Tooth Neuropathy Can Be Characterised by Both Cochlear and Neural Deficits<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29063243\" target=\"_blank\" rel=\"noopener\">Characterization of Charcot-Marie-Tooth optic neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29266326\" target=\"_blank\" rel=\"noopener\">Fifteen-year longitudinal follow-up of a patient with severe early-onset Charcot-Marie-Tooth disease type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30017354\" target=\"_blank\" rel=\"noopener\">Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/science.sciencemag.org\/content\/360\/6386\/336\" target=\"_blank\" rel=\"noopener\">MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28796392\" target=\"_blank\" rel=\"noopener\">Natural history of Charcot-Marie-Tooth disease during childhood.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27907123\" target=\"_blank\" rel=\"noopener\">Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb\/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.nature.com\/nature\/journal\/vaap\/ncurrent\/full\/nature20156.html#author-information\" target=\"_blank\" rel=\"noopener\">Correcting mitochondrial fusion by manipulating mitofusin conformations<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25430934\">CMT subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium natural history study: a cross-sectional analysis.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25448007\">Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24333\/full\" target=\"_blank\" rel=\"noopener\">Prospective study of muscle cramps in Charcot-Marie-Tooth disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26263471\">Update on Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25253751\">Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25614874\">The allelic spectrum of Charcot-Marie-Tooth disease in over 17,000 individuals with neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1511\/\">Charcot-Marie-Tooth Neuropathy Type 2A<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21288981\">TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21254193\">Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21508331\">MFN2 mutations cause severe phenotypes in most patients with CMT2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21327736\">Recent advances in the genetics of hereditary axonal sensory-motor neuropathies type 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21254193\">A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21987543\">Large kindred evaluation of mitofusin 2 novel mutation, extremes of neurologic presentations, and preserved nerve mitochondria.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20163430\">Mechanisms of disease and clinical features of mutations of the gene for mitofusin 2: an important cause of hereditary peripheral neuropathy with striking clinical variability in children and adults.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17959936\">Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17959936\">Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19019301\">Experimental therapeutics in hereditary neuropathies: the past, the present, and the future.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/jcb.rupress.org\/content\/176\/4\/405.abstract\">Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17959936\">Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/mda.org\/quest\/researchers-studying-cmt1b-cmt2a-cmt4a-cmt4c-others\">MITOFUSIN 2; MFN2<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/mda.org\/quest\/researchers-studying-cmt1b-cmt2a-cmt4a-cmt4c-others\">Researchers Studying CMT1B, CMT2A, CMT4A, CMT4C, Others<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21987543\">CONCERNING THE IMMUNITIES OF TOLERANCE: A PRELIMINARY COMMUNICATION.<br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25448007\">Charcot-Marie-Tooth Neuropathy Type 2A.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>BRASIL<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21531138\">Characterizing the phenotypic manifestations of MFN2 R104W mutation in Charcot-Marie-Tooth type 2.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>MEXICO<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18979992\">[Diagnosis of the peripheral hereditary neuropathies and its molecular genetics].<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>KOREA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24863639\" target=\"_blank\" rel=\"noopener\">A cohort study of MFN2 mutations and phenotypic spectrums in Charcot-Marie-Tooth disease 2A patients.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25258575\">Hereditary Motor and Sensory Neuropathy Type VI with Bilateral Middle Cerebellar Peduncle Involvement.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22526351\">A novel double mutation in cis in MFN2 causes Charcot-Marie-Tooth neuropathy type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20587496\">Early-onset Charcot-Marie-Tooth patients with mitofusin 2 mutations and brain involvement.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20587496\">Mitochondrial GTPase mitofusin 2 mutations in Korean patients with Charcot-Marie-Tooth neuropathy type 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16835246\">Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.progettomitofusina2.com\/immagini\/pdf\/200602002.pdf\">Charcot-Marie-Tooth Disease: Seventeen Causative Genes<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16835246\">Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>RUSSIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24450158\">[MFN2 gene analysis in patients with hereditary motor and sensory neuropathy from Bashkortostan Republic].<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11528513\">A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2F) maps to chromosome 7q11-q21<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10737979\">Screening for mutations in the peripheral myelin genes PMP22, MPZ and Cx32 (GJB1) in Russian Charcot-Marie-Tooth neuropathy patients<\/a><\/li>\n<\/ul>\n<hr \/>\n<p><strong>CHINA<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1873506119300418?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Generation of Induced Pluripotent Stem Cell Line, ZJUCHi002-A, From Charcot-Marie-Tooth Disease Type 2A (CMT2A) Patient With a Mutation of c.752C&gt;T in MFN2<\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31439445-corrigendum-to-generation-of-induced-pluripotent-stem-cell-line-zzui0012-a-from-a-patient-with-fahrs-disease-caused-by-a-novel-mutation-in-slc20a2-gene-stem-cell-research-volume-35-march-2019-101395\/\" target=\"_blank\" rel=\"noopener\">Corrigendum to &#8216;Generation of Induced Pluripotent Stem Cell Line (ZZUi0012-a) From a Patient With Fahr&#8217;s Disease Caused by a Novel Mutation in SLC20A2 Gene&#8217; [Stem Cell Research Volume 35, March 2019, 101,395]<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-12912-0\" target=\"_blank\" rel=\"noopener\">Structural Insights of Human mitofusin-2 Into Mitochondrial Fusion and CMT2A Onset<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/cge.13616\" target=\"_blank\" rel=\"noopener\">Genetic Spectrum and Clinical Profiles in a Southeast Chinese Cohort of Charcot-Marie-Tooth Disease<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26956144\">A novel p.Val244Leu mutation in MFN2 leads to Charcot-Marie-Tooth disease type 2.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26956144\">Late-onset hereditary sensory and autonomic neuropathy expands the phenotypic spectrum of MFN2-related diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30210586\" target=\"_blank\" rel=\"noopener\">Exome sequencing reveals a novel MFN2 missense mutation in a Chinese family with Charcot-Marie-Tooth type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19768354.2013.814587\" target=\"_blank\" rel=\"noopener\">Missense mutations of mitofusin 2 in axonal Charcot\u2013Marie\u2013Tooth neuropathy: polymorphic or incomplete penetration?<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22762946\">Mitofusin 2 gene mutation causing early-onset CMT2A with different progressive courses.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22653593\">A novel mutation of the MFN2 gene in a Chinese family with Charcot-Marie-Tooth disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20804729\">Mitofusin-2 is a novel direct target of p53.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20580691\">Mitofusin-2 protects against cold stress-induced cell injury in HEK293 cells.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20580691\">[Mutation analysis of MFN2 gene in Chinese patients with Charcot-Marie-Tooth disease].<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20580691\"><br \/>\n<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18458227\">Severe early-onset axonal neuropathy with homozygous and compound heterozygous MFN2 mutations.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>JAPAN<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213007122000235\">Multiple respiratory complications in a patient with Charcot-Marie-Tooth disease with MFN2 mutation<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29215088\" target=\"_blank\" rel=\"noopener\">Charcot-Marie-Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28660751\" target=\"_blank\" rel=\"noopener\">Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case study.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20800346\">Late-onset CMT2 associated with a novel missense mutation in the cytoplasmic domain of the MPZ gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19690333\">The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19690333\">Mitofusin 2 inhibits mitochondrial antiviral signaling.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15549395\">Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>TAIWAN<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22206013\">The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>AUSTRALIA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29068134\">Structure, function, and regulation of mitofusin-2 in health and disease.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29068134\">Severe early-onset axonal neuropathy with homozygous and compound heterozygous MFN2 mutations.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>CANADA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/20865121\">http:\/\/www.ncbi.nlm.nih.gov\/20865121<\/a><\/li>\n<li><a href=\"https:\/\/charcot-marie-toothnews.com\/2021\/03\/17\/large-study-on-cmt2a-natural-history-links-genetic-variants-and-severity\/?fbclid=IwAR0zZ9SiiPylGpaK-kohbtJe7f88doNQg-9LHGBdMvxSYVJXaEGxt5Fvcyg\" target=\"_blank\" rel=\"noopener\">CMT2A Study Links Genetic Variants to Disease Severity<\/a><\/li>\n<\/ul>\n<hr \/>\n<p><strong>\u00a0FINLAND<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28810241\" target=\"_blank\" rel=\"noopener\">Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23963299\">Targeted next-generation sequencing reveals further genetic heterogeneity in axonal Charcot-Marie-Tooth neuropathy and a mutation in HSPB1.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24530046\">Novel mitofusin 2 splice-site mutation causes Charcot-Marie-Tooth disease type 2 with prominent sensory dysfunction.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23456260\">Dominant GDAP1 founder mutation is a common cause of axonal Charcot-Marie-Tooth disease in Finland.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24450158\">[MFN2 gene analysis in patients with hereditary motor and sensory neuropathy from Bashkortostan Republic].<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9633821\">Spectrum of mutations in Finnish patients with Charcot-Marie-Tooth disease and related neuropathies.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3740791\">Charcot-Marie-Tooth disease in northern Finland.<\/a><\/li>\n<\/ul>\n<h3><\/h3>\n<hr \/>\n<h3>MAROCCO<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25459128\">[Review of the recent literature on hereditary neuropathies].<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>ALGERIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25454638\">Hereditary motor and sensory neuropathies or Charcot-Marie-Tooth diseases: an update.<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3>GREECE<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25417019\">Modeling protein misfolding in charcot-marie-tooth disease.<\/a><\/li>\n<\/ul>\n<h3>IRELAND<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27927941\" target=\"_blank\" rel=\"noopener\">A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland.<\/a><\/li>\n<\/ul>\n<h3>SAUDI ARABIA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30361041\">Mitochondrial dynamics: Biological roles, molecular machinery, and related diseases.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30361041\">Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30361041\">.<\/a><\/li>\n<\/ul>\n<h3><strong>HUNGARY<\/strong><\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29378182\">Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.<\/a><\/li>\n<\/ul>\n<p><strong>PAKISTAN<\/strong><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><a href=\"https:\/\/progettomitofusina2.com\/en\/risorse\/Affected%20Children%20of%20Healthy%20Parents:%20Multiple%20Pediatric%20Cases%20of%20Autosomal%20Recessive%20Charcot-Marie-Tooth%20Disease%20in%20a%20Pakistani%20Family\" target=\"_blank\" rel=\"noopener\">Affected Children of Healthy Parents: Multiple Pediatric Cases of Autosomal Recessive Charcot-Marie-Tooth Disease in a Pakistani Family<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2izlnq5-d9b83690d36c3a50098424d1c16e493b hr-full  avia-builder-el-2  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izmi2w-d6f641eff9d962c5b44bc3d64af27551 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>FRANCIA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31186069\">In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies<\/a>.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26686600\">Clinical and allelic heterogeneity in a pediatric cohort of 11 patients carrying MFN2 mutation.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29898954\" target=\"_blank\" rel=\"noopener\">Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26246519\">Charcot-Marie-Tooth diseases: an update and some new proposals for the classification.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24957169\">Charcot-Marie-Tooth disease type 2A: from typical to rare phenotypic and genotypic features<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22189565\">The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy &#8216;plus&#8217; phenotype.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22433900\">Standardized mitochondrial analysis gives new insights into mitochondrial dynamics and OPA1 function<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22546700\">A French family with Charcot-Marie-Tooth disease related to simultaneous heterozygous MFN2 and GDAP1 mutations<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23147504\">Mitochondria and peripheral neuropathies<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20849849\">Mitochondrial dysfunction and pathophysiology of Charcot-Marie-Tooth disease involving GDAP1 mutations<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21285398\">Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19718987\">[Ultrastructural lesions of axonal mitochondria in patients with childhood-onset Charcot-Marie-Tooth disease due to MFN2 mutations].<br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18957892\">Genotype-phenotype correlations in Charcot-Marie-Tooth disease type 2 caused by mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18957892\">Histopathological findings in hereditary motor and sensory neuropathy of axonal type with onset in early childhood associated with mitofusin 2 mutations.<br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17444508\">Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A disease.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2izmx7m-2f831a58ebb331673513ba6dce90ed28 hr-full  avia-builder-el-4  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izndfl-1e1c55521dd5266db505a52465c63390 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>GRAN BRETAGNA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30911005\">Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin<\/a>.<\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29520876\" target=\"_blank\" rel=\"noopener\">Severe cognitive impairment in a patient with CMT2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28063088\" target=\"_blank\" rel=\"noopener\">Mosaicism for a pathogenic MFN2 mutation causes minimal clinical features of CMT2A in the parent of a severely affected child.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26114802\">MFN2 deletion of exons 7 and 8: founder mutation in the UK population.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24198383\">Recessive axonal Charcot-Marie-Tooth disease due to compound heterozygous mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25582960\">A pilot study of proximal strength training in Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25519471\">Interventions for fatigue in peripheral neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23840650\">Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23840650\">Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2iznp0g-d897d3009bad76e27571908475e8cacd hr-full  avia-builder-el-6  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izo35a-5eef88e6e11ac561c69edd33edf40989 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>SPAGNA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30569560\">Genetic epidemiology, demographic and clinical characteristics of Charcot-Marie-Tooth disease in the island of Gran Canaria (Spain).<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25567790\">Mitofusin 2 as a driver that controls energy metabolism and insulin signaling.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26113818\">Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25567790\">Mitofusin 2 as a driver that controls energy metabolism and insulin signaling.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21703725\">[Guidelines for molecular diagnosis of Charcot-Marie-Tooth disease].<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20544920\">Charcot-Marie-Tooth disease with intermediate conduction velocities caused by a novel mutation in the MPZ gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19889647\">Phenotypic spectrum of MFN2 mutations in the Spanish population<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19448711\">Regulation of mitofusin-2 expression in skeletal muscle<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21703725\">Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2izoefh-eff1424a54fd6088dcf64f1d3ca5a51c hr-full  avia-builder-el-8  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izones-90038c984e56e734a8cf3f79159b3201 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>ISLANDA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19893324\">Prevalence of symptomatic Charcot-Marie-Tooth disease in Iceland: a study of a well-defined population.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2izozvr-5cb92992e4ce640eb57036a0e5a8d659 hr-full  avia-builder-el-10  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izp9s5-3c050b476ef89379fd4f3e7633d89829 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>SVIZZERA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28348166\">Mfn2 is critical for brown adipose tissue thermogenic function.<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22179580\">Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21526202\">An unusual splice defect in the mitofusin 2 gene (MFN2) is associated with degenerative axonopathy in Tyrolean Grey cattle<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/brain.oxfordjournals.org\/content\/133\/5\/1460\">Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot\u2013Marie\u2013Tooth neuropathy type 2A<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19427854\">Role of mitofusin 2 mutations in the physiopathology of Charcot-Marie-Tooth disease type 2A.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2izplfp-077a4fac6061864e5c8cbe03e96b733e hr-full  avia-builder-el-12  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izpuq4-18f565ae22cd268808244ad3495579ec '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>SERBIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21546779\">Epidemiology of Charcot-Marie-Tooth disease in the population of Belgrade, Serbia.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-14  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izr1dg-21d87347f2adbc94a004e88632766c83 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>SVEZIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25286435\">Exploratory study of physical activity in persons with Charcot-Marie-Tooth disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18579801\">Adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1049919\/\">Charcot-Marie-Tooth disease in northern Sweden: pedigree analysis and the presence of the duplication in chromosome 17p11.2.<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8333247\">Charcot-Marie-Tooth disease in northern Sweden: an epidemiological and clinical study<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-16  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2iztcsk-395b42a92b805fee7b59ccc92111e5fb '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>BELGIO<\/h3>\n<ul>\n<li><a href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs13311-016-0501-z\" target=\"_blank\" rel=\"noopener\">Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006899320300482?via%3Dihub\" target=\"_blank\" rel=\"noopener\">HDAC6 Inhibitors: Translating Genetic and Molecular Insights Into a Therapy for Axonal CMT<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21840889\">Genetic spectrum of hereditary neuropathies with onset in the first year of life.<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16714318\">MFN2 mutation distribution and genotype\/phenotype correlation in Charcot-Marie-Tooth type 2.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-18  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2iztyuy-8576698eab44616b8781cbc6a1082642 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>GERMANIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25850958\">Diagnostic algorithms in Charcot-Marie-Tooth neuropathies: experiences from a German genetic laboratory on the basis of 1206 index patients<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25688136\">Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22926664\">Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23711354\">Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23743332\">Charcot-Marie-Tooth disease: frequency of genetic subtypes in a German neuromuscular center population<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18826755\">Late onset autosomal dominant Charcot-Marie-Tooth 2 neuropathy in a Costa Rican family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18425620\">Cerebral involvement in axonal Charcot-Marie-Tooth neuropathy caused by mitofusin2 mutations.<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18826755\"><br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16762064\">Charcot-Marie-Tooth neuropathy type 2A: novel mutations in the mitofusin 2 gene (MFN2).<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19109886\">Mitofusin 2 builds a bridge between ER and mitochondria<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18425620\">Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A).<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-20  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izujp5-12ab4d3922c36b5b112a993e1ec254bf '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>NORVEGIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23106488\">Genetic epidemiology of Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.biomedcentral.com\/1471-2350\/11\/48\"><em>MFN2<\/em>\u00a0point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20482598\">Genetic epidemiology of Charcot-Marie-Tooth in the general population.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.biomedcentral.com\/1471-2350\/14\/94\">Diagnostic laboratory testing for Charcot Marie Tooth disease (CMT): the spectrum of gene defects in Norwegian patients with CMT and its implications for future genetic test strategies<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-22  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izvbgl-b9499a484ad7317cb751db0c48554407 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>AUSTRIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21892769\">SNP array-based whole genome homozygosity mapping as the first step to a molecular diagnosis in patients with Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-24  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izvu4g-5d325eb8ca565472a6be64a6f426dd92 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>CIPRO<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20571287\">Charcot-Marie-Tooth disease in Cyprus: epidemiological, clinical and genetic characteristics.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-26  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izw9q3-8fd92abef3c16cfe697bdb0a6a8617f0 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>POLONIA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30442897\">Molecular modelling of mitofusin 2 for a prediction for Charcot-Marie-Tooth 2A clinical severity.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28076385\" target=\"_blank\" rel=\"noopener\">The Effect of a Novel c.820C>T (Arg274Trp) Mutation in the Mitofusin 2 Gene on Fibroblast Metabolism and Clinical Manifestation in a Patient.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25574749\">Mitofusin 2 expression dominates over mitofusin 1 exclusively in mouse dorsal root ganglia &#8211; a possible explanation for peripheral nervous system involvement in Charcot-Marie-Tooth 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24803844\">A late-onset and mild form of Charcot-Marie-Tooth disease type 2 caused by a novel splice-site mutation within the Mitofusin-2 gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17874344\">[Mutations in the mitofusin 2 gene are the most common cause of Charcot-Marie-Tooth type 2 disease].<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-28  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izwt0u-1bc78815e1c6d57ce2c7ac8e7a4a07b5 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>TURCHIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19381883\">Novel GDAP1 mutation in a Turkish family with CMT2K (CMT2K with novel GDAP1 mutation).<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-30  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izxlri-027aaf12ac5bc34c7b6486d53c4e1e8a '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>USA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14992027.2019.1633022\" target=\"_blank\" rel=\"noopener\">The Audiologic Profile of Patients With Charcot-Marie Tooth Neuropathy Can Be Characterised by Both Cochlear and Neural Deficits<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31188717\">Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2<\/a>.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31336816\">Charcot-Marie-Tooth: From Molecules to Therapy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30642740\">A novel MFN2 mutation causes variable clinical severity in a multi-generational CMT2 family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30649465\">MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30882371\">Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31127728\">Late onset CMT2A in a Family with an MFN2 Variant: c.2222T>G (p.Leu741Trp)<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31231042\">Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29063243\">Characterization of Charcot-Marie-Tooth optic neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29341354\">A mutation in the heptad repeat 2 domain of MFN2 in a large CMT2A family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29341354\">Fifteen-year longitudinal follow-up of a patient with severe early-onset Charcot-Marie-Tooth disease type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29266326\" target=\"_blank\" rel=\"noopener\">Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/science.sciencemag.org\/content\/360\/6386\/336\" target=\"_blank\" rel=\"noopener\">MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28796392\" target=\"_blank\" rel=\"noopener\">Natural history of Charcot-Marie-Tooth disease during childhood.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27907123\" target=\"_blank\" rel=\"noopener\">Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb\/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27907123\" target=\"_blank\" rel=\"noopener\">Correcting mitochondrial fusion by manipulating mitofusin conformations<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25430934\">CMT subtypes and disease burden in patients enrolled in the Inherited Neuropathies Consortium natural history study: a cross-sectional analysis.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25448007\">Axonal Charcot-Marie-Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.24333\/full\" target=\"_blank\" rel=\"noopener\">Prospective study of muscle cramps in Charcot-Marie-Tooth disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26263471\">Update on Charcot-Marie-Tooth disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25253751\">Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25614874\">The allelic spectrum of Charcot-Marie-Tooth disease in over 17,000 individuals with neuropathy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1511\/\">Charcot-Marie-Tooth Neuropathy Type 2A<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21288981\">TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21254193\">Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21508331\">MFN2 mutations cause severe phenotypes in most patients with CMT2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21327736\">Recent advances in the genetics of hereditary axonal sensory-motor neuropathies type 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21254193\">A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21987543\">Large kindred evaluation of mitofusin 2 novel mutation, extremes of neurologic presentations, and preserved nerve mitochondria.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20163430\">Mechanisms of disease and clinical features of mutations of the gene for mitofusin 2: an important cause of hereditary peripheral neuropathy with striking clinical variability in children and adults.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17959936\">Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17959936\">Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19019301\">Experimental therapeutics in hereditary neuropathies: the past, the present, and the future.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/jcb.rupress.org\/content\/176\/4\/405.abstract\">Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17959936\">Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/mda.org\/quest\/researchers-studying-cmt1b-cmt2a-cmt4a-cmt4c-others\">MITOFUSIN 2; MFN2<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/mda.org\/quest\/researchers-studying-cmt1b-cmt2a-cmt4a-cmt4c-others\">Researchers Studying CMT1B, CMT2A, CMT4A, CMT4C, Others<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21987543\">CONCERNING THE IMMUNITIES OF TOLERANCE: A PRELIMINARY COMMUNICATION.<br \/>\n<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25448007\">Charcot-Marie-Tooth Neuropathy Type 2A.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-l2izxy4u-eabc1ec244db2d05b0e6554b58c053d1 hr-full  avia-builder-el-32  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izyakw-280ac88c7bd9e271a99d253004c05437 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>BRASILE<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25515278\" target=\"_blank\" rel=\"noopener\">Sleep pattern in Charcot-Marie-Tooth disease type 2: report of family case series.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21531138\">Characterizing the phenotypic manifestations of MFN2 R104W mutation in Charcot-Marie-Tooth type 2.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-34  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izyo3t-abd2ca7f5691f73bd414667c4180875d '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>MESSICO<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18979992\">[Diagnosis of the peripheral hereditary neuropathies and its molecular genetics].<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-36  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izz38d-7e488d40d2394003db8f8f800be5f45f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>KOREA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24863639\" target=\"_blank\" rel=\"noopener\">A cohort study of MFN2 mutations and phenotypic spectrums in Charcot-Marie-Tooth disease 2A patients.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25258575\">Hereditary Motor and Sensory Neuropathy Type VI with Bilateral Middle Cerebellar Peduncle Involvement.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22526351\">A novel double mutation in cis in MFN2 causes Charcot-Marie-Tooth neuropathy type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20587496\">Early-onset Charcot-Marie-Tooth patients with mitofusin 2 mutations and brain involvement.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20587496\">Mitochondrial GTPase mitofusin 2 mutations in Korean patients with Charcot-Marie-Tooth neuropathy type 2.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16835246\">Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.progettomitofusina2.com\/immagini\/pdf\/200602002.pdf\">Charcot-Marie-Tooth Disease: Seventeen Causative Genes<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16835246\">Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A.<br \/>\n<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-38  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2izzq2u-328ae7839236f4584b7c808a861a8561 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>RUSSIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24450158\">[MFN2 gene analysis in patients with hereditary motor and sensory neuropathy from Bashkortostan Republic].<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11528513\">A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2F) maps to chromosome 7q11-q21<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10737979\">Screening for mutations in the peripheral myelin genes PMP22, MPZ and Cx32 (GJB1) in Russian Charcot-Marie-Tooth neuropathy patients<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-40  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j008lv-23cde16d56a899046a0c55b34cb85c11 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>CINA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1873506119300418?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Generation of Induced Pluripotent Stem Cell Line, ZJUCHi002-A, From Charcot-Marie-Tooth Disease Type 2A (CMT2A) Patient With a Mutation of c.752C>T in MFN2<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31439445-corrigendum-to-generation-of-induced-pluripotent-stem-cell-line-zzui0012-a-from-a-patient-with-fahrs-disease-caused-by-a-novel-mutation-in-slc20a2-gene-stem-cell-research-volume-35-march-2019-101395\/\" target=\"_blank\" rel=\"noopener\">Corrigendum to &#8216;Generation of Induced Pluripotent Stem Cell Line (ZZUi0012-a) From a Patient With Fahr&#8217;s Disease Caused by a Novel Mutation in SLC20A2 Gene&#8217; [Stem Cell Research Volume 35, March 2019, 101,395]<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-019-12912-0\" target=\"_blank\" rel=\"noopener\">Structural Insights of Human mitofusin-2 Into Mitochondrial Fusion and CMT2A Onset<\/a><\/li>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/cge.13616\" target=\"_blank\" rel=\"noopener\">Genetic Spectrum and Clinical Profiles in a Southeast Chinese Cohort of Charcot-Marie-Tooth Disease<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26956144\">A novel p.Val244Leu mutation in MFN2 leads to Charcot-Marie-Tooth disease type 2.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30011089\">Late-onset hereditary sensory and autonomic neuropathy expands the phenotypic spectrum of MFN2-related diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30210586\" target=\"_blank\" rel=\"noopener\">Exome sequencing reveals a novel MFN2 missense mutation in a Chinese family with Charcot-Marie-Tooth type 2A.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19768354.2013.814587\" target=\"_blank\" rel=\"noopener\">Missense mutations of mitofusin 2 in axonal Charcot\u2013Marie\u2013Tooth neuropathy: polymorphic or incomplete penetration?<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22762946\">Mitofusin 2 gene mutation causing early-onset CMT2A with different progressive courses.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22653593\">A novel mutation of the MFN2 gene in a Chinese family with Charcot-Marie-Tooth disease<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20804729\">Mitofusin-2 is a novel direct target of p53.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20580691\">Mitofusin-2 protects against cold stress-induced cell injury in HEK293 cells.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20580691\">[Mutation analysis of MFN2 gene in Chinese patients with Charcot-Marie-Tooth disease].<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20580691\"><br \/>\n<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18458227\">Severe early-onset axonal neuropathy with homozygous and compound heterozygous MFN2 mutations.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-42  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j00tw9-7c330bfac1815d728bcf3c9f453ad6de '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>GIAPPONE<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213007122000235\" target=\"_blank\" rel=\"noopener\">Multiple respiratory complications in a patient with Charcot-Marie-Tooth disease with MFN2 mutation<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29215088\" target=\"_blank\" rel=\"noopener\">Charcot-Marie-Tooth disease type 2A with an autosomal-recessive inheritance: the first report of an adult-onset disease.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28660751\" target=\"_blank\" rel=\"noopener\">Clinical and genetic diversities of Charcot-Marie-Tooth disease with MFN2 mutations in a large case study.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20800346\">Late-onset CMT2 associated with a novel missense mutation in the cytoplasmic domain of the MPZ gene.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19690333\">The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19690333\">Mitofusin 2 inhibits mitochondrial antiviral signaling.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15549395\">Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-44  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j01dqb-09b9ffc6f846aef2c19f68ddd351f13c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>TAIWAN<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22206013\">The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-46  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j01q2j-cba1c9cacbce7182cea5deddb1a3e94f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>AUSTRALIA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29068134\">Structure, function, and regulation of mitofusin-2 in health and disease.<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29068134\">Severe early-onset axonal neuropathy with homozygous and compound heterozygous MFN2 mutations.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-48  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j02a8q-08756e8612d31434c5884f339ab7374c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>CANADA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/20865121\">http:\/\/www.ncbi.nlm.nih.gov\/20865121<\/a><\/li>\n<li><a href=\"https:\/\/charcot-marie-toothnews.com\/2021\/03\/17\/large-study-on-cmt2a-natural-history-links-genetic-variants-and-severity\/?fbclid=IwAR0zZ9SiiPylGpaK-kohbtJe7f88doNQg-9LHGBdMvxSYVJXaEGxt5Fvcyg\" target=\"_blank\" rel=\"noopener\">CMT2A Study Links Genetic Variants to Disease Severity<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-50  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j02oqi-d21edbcd911413d94131a8d69123ebd4 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><b>\u00a0FINLANDIA<\/b><\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28810241\" target=\"_blank\" rel=\"noopener\">Molecular Epidemiology of Charcot-Marie-Tooth Disease in Northern Ostrobothnia, Finland: A Population-Based Study.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23963299\">Targeted next-generation sequencing reveals further genetic heterogeneity in axonal Charcot-Marie-Tooth neuropathy and a mutation in HSPB1.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24530046\">Novel mitofusin 2 splice-site mutation causes Charcot-Marie-Tooth disease type 2 with prominent sensory dysfunction.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23456260\">Dominant GDAP1 founder mutation is a common cause of axonal Charcot-Marie-Tooth disease in Finland.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24450158\">[MFN2 gene analysis in patients with hereditary motor and sensory neuropathy from Bashkortostan Republic].<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9633821\">Spectrum of mutations in Finnish patients with Charcot-Marie-Tooth disease and related neuropathies.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3740791\">Charcot-Marie-Tooth disease in northern Finland.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-52  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j033rm-54893d02c97f3c4c19a5a2881720a871 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><b>MAROCCO<\/b><\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25459128\">[Review of the recent literature on hereditary neuropathies].<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-54  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j03icq-966005bee403febdd2008b0cffd7933f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>ALGERIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25454638\">Hereditary motor and sensory neuropathies or Charcot-Marie-Tooth diseases: an update<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-56  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j03x2s-f2ed23b470a730baf3b545b8a8560b2c '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>GRECIA<\/h3>\n<ul>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25417019\">Modeling protein misfolding in charcot-marie-tooth disease.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-58  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j04b2x-758d98daa849fbe7b6fb895858a8443b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>IRLANDA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27927941\" target=\"_blank\" rel=\"noopener\">A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-60  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j04rqi-07bfa41773caad691e6a6127996fa4c2 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3>ARABIA SUDITA<\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31453851\">Novel MFN2 Missense Mutation Induces Hereditary Axonal Motor and Sensory Neuropathy in a Saudi Arabian Family<\/a>.<\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30361041\">Mitochondrial dynamics: Biological roles, molecular machinery, and related diseases.<\/a><\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30361041\">Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-62  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j0581g-1e45c858b30a9927685c887664e30926 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><strong>UNGHERIA<\/strong><\/h3>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29378182\">Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n<div  class='hr av-av_hr-ab1280f24c7ec2564077419fd2b6bdc2 hr-full  avia-builder-el-64  el_after_av_textblock  el_before_av_textblock  hr-no-shadow'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-l2j05x5c-5e1f60da1454b848afb30b8fd1efadf5 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h3><strong>PACHISTAN<br \/>\n<\/strong><\/h3>\n<ul>\n<li><a href=\"https:\/\/www.cureus.com\/articles\/19003-affected-children-of-healthy-parents-multiple-pediatric-cases-of-autosomal-recessive-charcot-marie-tooth-disease-in-a-pakistani-family\" target=\"_blank\" rel=\"noopener\">Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.<\/a><\/li>\n<\/ul>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":2222,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2226","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/pages\/2226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/comments?post=2226"}],"version-history":[{"count":9,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/pages\/2226\/revisions"}],"predecessor-version":[{"id":4505,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/pages\/2226\/revisions\/4505"}],"up":[{"embeddable":true,"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/pages\/2222"}],"wp:attachment":[{"href":"https:\/\/www.progettomitofusina2.com\/en\/wp-json\/wp\/v2\/media?parent=2226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}